Anti-Aging 2.0, Growth Factor Serums

Best Growth Factor Serums

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Growth factor skincare products are the new anti-aging frontier. It’s because growth factors offer a new way of renewing skin, which doesn’t involve skin peeling, flaking, or irritation. They’re like anti-aging 2.0! But there’s a catch. Growth factors are incredibly expensive to harvest and formulate into products. And growth factor serums are some of the most expensive anti-aging products out there.

So you need to think twice before splurging on one and know what you’re buying. If you skipped our guide to growth factors in skincare, here’s the recap. Growth factors (GF), which is the umbrella term for different types of growth factors, are proteins that are present in your skin.

Some of them are epidermal growth factors (EGF), platelet-derived growth factors (PGF), and fibroblast growth factors (FGF). They do several tasks like making sure your skin heals properly, there’s new collagen cooking up, and skin cells renew regularly.

And growth factor serums are born as a result of an attempt to replicate this process. Growth factor serums improve skin texture and tone and aid in skin repair from sun damage and other stressors. If you’re ready to try one, below are some of the best growth factor serums and things to keep in mind to find the right one for your skin.

How to Choose a Growth Factor Serum

Choose the Right Type of Growth Factors

Growth factors can be derived from either human skin cells or plants and bacteria. Human growth factors obtain their GF from human skin cells under laboratory conditions. These cells are usually obtained once to be utilized several times and are sourced from cell banks. These contain tens or hundreds of growth factors.

In the second option, they single out growth factors from bacteria or some other source and only put in a single growth factor in your serum. The consensus is that the more growth factors there are in your product, the better it will work for your skin. That’s why human growth factors are the better option for maximum results.

Choose Quality Brands

The whole process of obtaining growth factors is costly. That’s why these products are so expensive. There’s this conversation about whether expensive products are better than cheaper ones. In the case of growth factor serums, the answer is yes.

Expensive is better because high-end skincare brands are the ones that can afford to manufacture these ingredients, do proper clinical research, and create something that works. So instead of experimenting with unknown brands, stick with quality, reliable brands to get the most out of your serum.

Keep Your Skin Concerns in Mind

Growth factor serums are anti-aging products. They help promote collagen production and soften the appearance of wrinkles, fine lines, and loss of skin elasticity. You’ll see that most of them are minimal and don’t contain a lot of ingredients.

This makes sense. But if you’re dealing with a particular problem like uneven skin tone or if you have a lot of sun damage, it doesn’t hurt to have your growth factor serum also contain brightening antioxidants like vitamin C.

Keep Your Skin Type in Mind

As with any type of skincare product, you still need to keep your skin type in mind when choosing a growth factor serum. Otherwise, you might end up with clogged pores, irritation, or even blemishes.

If your skin is oily or acne-prone, go for oil-free growth factor serums or at least make sure it’s labeled non-comedogenic. If you have sensitivity, avoid alcohol or high concentration fragrance in your serums.

Best Growth Factor Serums

1. SkinMedica TNS Recovery Complex

SkinMedica TNS Recovery Complex - Best Growth Factor Serums

Because they’re the pioneers in this department, SkinMedica offers some of the best medical-grade growth factor products. And they have their original publishings demonstrating that their products work. This serum contains human growth factors.

And because of that, it’s practically a variety of different types of growth factors to better target signs of aging. The gel formula is super minimal and incredibly targeted. It repairs sun-damaged, rough skin, improves uneven skin texture, and promotes collagen and elastin growth.

Key Ingredients: GF
Size: 1 oz/30 ml
Good to Know: Paraben-free, oil-free, silicone-free

2. Neocutis BIO Serum Firm Rejuvenating Growth Factor and Peptide Treatment

Neocutis BIO Serum Firm Rejuvenating Growth Factor and Peptide Treatment - Best Growth Factor Serums

Peptides are a chain of amino acids. And growth factors are basically a chain of peptides. In skincare products, they actually complement each other. And this potent growth factor serum combines the two to stimulate collagen synthesis and skin renewal. It’s made with human growth factors to reduce and soften the appearance of wrinkles and lines.

And it packs signal peptides, which nudge the skin into producing new collagen. The growth factor serum also contains the antioxidants vitamin C and vitamin E for added free radical protection, and acetyl glucosamine to target discolorations. Plus, you get immediate skin-plumping benefits from hyaluronic acid and squalane too.

Key Ingredients: GF, peptides, hyaluronic acid
Size: 1 oz/30 ml
Good to Know: Fragrance-free

3. Osmosis Beauty StemFactor Growth Factor Serum

Osmosis Beauty StemFactor Growth Factor Serum

With growth factors, there’s an ongoing conversation regarding skin penetration. Some parties offer alternative methods to make sure that growth factors penetrate the skin and actually work. On a side note, serums seem to be superior to creams, so no need to worry.

But because of these concerns, growth factors are sometimes micro-encapsulated to ensure maximum skin absorption. A great example of that is this serum that contains human growth factors and claims to accommodate 600 of them! It’s laser-focused on anti-aging skincare with growth factors and has no interest in hydrating or moisturizing your skin. It’s practically a bottle of skin-boosting proteins!

Key Ingredients: GF
Size: 1 oz/30 ml

4. StackedSkincare EGF Activating Serum

StackedSkincare EGF Activating Serum - Best EGF Growth Factor Serums

This growth factor serum belongs to the second category where no human skin cell is involved. It’s made with an epidermal growth factor, sh-oligopeptide-1. Even though this is an antioxidant-rich anti-aging serum, it’s actually made with acne-prone skin in mind.

Because growth factors are also anti-inflammatory and helpful in skin healing, the serum aids in speeding up the acne healing process. To amplify the results, the serum also contains anti-inflammatory green tea to calm inflamed skin.

Key Ingredients: GF, green tea, aloe
Size: 1 oz/30 ml

5. Jan Marini Transformation Face Serum

Jan Marini Transformation Face Serum - Best Oil-Free Growth Factor Serums

This is an all-in-one anti-aging serum that’s like a workaround for anyone who can’t tolerate exfoliants, retinoids, or other potentially irritating active ingredients. The oil-free serum has a light, hydrating base made with humectants like glycerin, hyaluronic acid, and sodium PCA.

They plump the skin instantly and reduce the appearance of fine lines. And it has transforming growth factor beta-1, a cytokine, another type of growth factor, that’s super important in collagen production.

Key Ingredients: GF, hyaluronic acid
Size: 1 oz/30 ml
Good to Know: Oil-free, non-comedogenic

6. The Inkey List 15% Vitamin C and EGF Brightening Serum

The Inkey List 15% Vitamin C and EGF Brightening Serum - Best Affordable Growth Factor Serums

And lastly, I wanted to include this affordable growth factor serum along with my two cents. If you want to try growth factors with a budget-friendly option, you can consider this one. But personally, I think that any skin benefit you’ll get from this is probably from vitamin C.

It has one single growth factor, which is plant-derived. Well, I’m not a chemist nor a dermatologist or whoever it is that would count as an authority. But I know my growth factors. That being said, the serum packs a vitamin C derivative to brighten the skin and fend off free radicals, making it a nice, affordable growth factor adjacent serum.

Key Ingredients: GF, vitamin C
Size: 1 oz/30 ml
Good to Know: Cruelty-free, vegan


So these are some of the best growth factors serums out there. And they’re great for people with mature, sensitive skin, who are looking for alternatives to major anti-aging ingredients. So if you’re not happy with treatments causing peeling or redness, growth factor serums, especially the human growth factor serums, are great.

In my opinion, SkinMedica offers the best growth factor serum. First of all, the formula is suitable for all skin types, including acne-prone, because of how lightweight it is. But more importantly, it contains human growth factors, which are way superior to plant-derived options and they utilized a patented formula. It’s a rich blend of growth factors and their formula is proven to work. So if you’re going to use a GF serum, you might as well go for one backed by science.

Read Next: Best Products to Smooth Out Uneven Skin Texture

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