The Best Peptide Eye Creams To Revitalize Your Under-Eyes

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Best Peptide Eye Creams

Now that peptides had their trial run in the form of serums and creams, we have peptide eye creams taking over the skincare world by storm. And it makes sense! Because peptides, or polypeptides, are basically chains of amino acids. And they’re an uncomplicated bunch. Once you know which one works on what, you can make use of peptides in your eye creams for pretty much anything. Whether it’s for under-eye bags, under-eye wrinkles, crow’s feet, or dark circles, peptide eye creams do have serious anti-aging benefits for the eye area.

So what does a peptide eye cream do exactly? The benefit of a peptide eye cream will depend largely on which one of the three types of peptides it contains.

In case you missed our guide to peptides, they’re classified into three. For example, eye creams with neuropeptides are touted to be nature’s Botox, which is amazing when you want to soften fine lines instantly (1). Signal peptide eye creams help boost collagen production and firm the skin around the eyes (2). Copper peptide eye creams have anti-inflammatory and antioxidant benefits.

So depending on what you’re dealing with, you can look for the right set of peptides in your eye cream. However, know that peptides don’t show up as peptides on your ingredient list. They show up with their official names.

For example, a copper peptide eye cream will have tripeptide-1 on the ingredient list, which is the most common one used in skincare.

A signal peptide eye cream will usually show palmitoyl tripeptide-1 or palmitoyl oligopeptide, commonly known as Matrixyl, which is the brand name of that specific peptide.

Similarly, a neuropeptide eye cream will usually have acetyl hexapeptide-8, commonly known as Argireline, on the list. This is to give you an overall idea about these ingredients.

If you’re interested in learning about them, refer to the end of the page and check out the first reference for a more comprehensive list of trademarked peptides.

Usually, eye creams contain multiple peptides from the same category to maximize the effects. And also, some eye creams contain two or all three types of peptides, which makes them incredibly multi-tasking too!

The good thing is you don’t need to look up anything. I’ve rounded up the best peptide eye creams below. And I’ll dive into each one and tell you which peptides it contains to help you look past vague terms like “firming peptides” or “collagen peptides”.

The Best Peptide Eye Creams

Find below the best peptide eye creams to tackle fine lines, wrinkles, under-eye bags, and more!

Peter Thomas Roth Peptide 21 Wrinkle Resist Eye Cream

Peter Thomas Roth Peptide 21 Wrinkle Resist Eye Cream - Best Peptide Eye Cream For Dark Circles

This is a very unique and rare formula because it combines all three major types of peptides in your eye cream. It’s made with signal peptides, neuropeptides, and copper peptides. And it’s just as potent as the serum in the collection. It helps soften the look of wrinkles, and fine lines under the eyes. And it replenishes dehydrated skin with its rich, moisturizing formula. In case you’re not familiar, another eye cream by the brand has recently gained popularity on TikTok because it instantly eliminated under-eye bags on a sweet old lady.

So PTR knows a thing or two (hundred) about firming the eye area. Plus, the eye cream contains a blend of propriety ingredients for tackling dark circles. So if you’re looking for a multi-tasking formula to soften wrinkles, rejuvenate the eye area, and achieve healthier-looking skin, this one is an amazing peptide eye cream full to the brim with polypeptides.

Dr. Brandt Do Not Age Triple Peptide Eye Cream

Dr. Brandt Do Not Age Triple Peptide Eye Cream - Best Peptide Eye Cream For Bags

An absolute go-to for anyone who wants to target the delicate skin around the eyes is this potent formula. It utilizes both signal peptides and neuropeptides. So it addresses wrinkles around the eyes by stimulating collagen production and also by temporarily smoothing them out. Additionally, it has a third peptide, which is a relatively new ingredient, but basically works as a vitamin C derivative.

And to better address dark circles, the eye cream combines the vitamin C derivative with caffeine. So overall, you can use the gentle formula to soften the appearance of wrinkles and brighten the under-eye area. Plus, you have instant plumping benefits all thanks to ceramides delivered into the skin with a fragrance-free base.

Drunk Elephant Shaba Complex Firming Eye Serum

Drunk Elephant Shaba Complex Firming Eye Serum

This one combines copper peptides with signal peptides in an eye serum. First of all, the mere fact that this is in serum form simply increases your chances of getting more noticeable results from your product. It packs humectants like vitamin B5 and hyaluronic acid. So the light, gel-like texture disappears into the skin and absorbs super fast. The fragrance-free peptide eye serum improves skin elasticity around the eyes to give the eye area a firmer appearance.

Again, copper peptides have antioxidant benefits. By adding vitamin E, and coenzymeQ10 into the mix, the formula protects the eye area from the damaging effects of free radicals. It also helps with discolorations around the eyes with niacinamide. So overall, the peptide eye serum is perfect for anyone looking for a gentle anti-aging under-eye product to freshen up the eyes.

Strivectin Peptight 360 Tightening Eye Serum

Strivectin Peptight 360 Tightening Eye Serum

Similarly, this one is also in serum form for enhancing the penetration of the peptides. But the best thing about this one is that you can use it all around the eye area including the upper eyelids. And that’s great when you generally deal with puffy eyes.

Personally, I have to put my Jade roller in the fridge to use the next day if I’m even thinking about getting a drink. The cooling massage helps with puffiness. But this peptide eye serum has an applicator tip you can use to depuff the eyes, get rid of eye bags, and work the product into the skin. Plus, it has niacinamide and caffeine to reduce dark circles and tighten the skin too.

iS Clinical Youth Eye Complex

iS Clinical Youth Eye Complex

This one utilizes a neuropeptide, which works by reducing muscle contraction and easing the look of expression lines around the eyes. And it contains a signal peptide, which renews and firms the skin. Lastly, it packs a copper peptide, which works as an antioxidant and helps with skin repair. The peptide eye treatment has Lipotec written all over it.

They’re the company behind Argireline, the famous peptide that mimics Botox. The eye cream instantly plumps the skin with hyaluronic acid and panthenol and also soothes the eye area with Centella Asiatica. So if you’re looking for a potent anti-aging formula for mature skin, deep wrinkles, fine lines, dehydration lines, and sun damage around the eyes, this is a well-deserving investment.

Derma-E Advanced Peptides & Collagen Eye Cream

Derma-E Advanced Peptides & Collagen Eye Cream - Best Affordable  Peptide Eye Cream

If you’re looking for an affordable peptide eye cream, this can be as helpful as the rest. Besides signal peptides and neuropeptides, this one’s got a blend of antioxidants like green tea, vitamins A, C, and E to undo sun damage around the eyes.

But it also has a very moisturizing texture, which is amazing if you have very dry under-eyes. It instantly plumps up the skin and fills in fine lines with humectants and emollients like glycerin, macadamia seed oil, and collagen fractions.

Biossance Squalane + Peptide Eye Gel

Biossance Squalane + Peptide Eye Gel

Some people don’t enjoy a heavily occlusive eye cream because it can cause milia. When that’s the case, eye serums and eye gels are the way to go. They don’t contain comedogenic oils. So the light texture of this one is perfect if you’re prone to milia. Additionally, if you’re an instant gratification seeker like me, this one is made with neuropeptides only.

So you’ll get instantly smooth skin around the eyes all thanks to Argireline, and another neuropeptide by Lipotec with advanced depuffing benefits. To quench dry and dehydrated skin around the eyes, the eye gel has squalane, aloe, panthenol, and hyaluronic acid. And it packs caffeine to better address puffy eyes. It’s clean, vegan, cruelty-free, and an effective peptide eye cream to renew the eye area when you don’t want to deal with irritating ingredients.

Exuviance Age Reverse Eye Contour

Exuviance Age Reverse Eye Contour

Speaking of irritating ingredients, not all skin types can tolerate exfoliants, especially when it comes to the under-eye area. On the flip side, exfoliating the skin around the eyes is super helpful in getting rid of flaky under-eyes, loose skin, and fine lines. For that reason, this is my personal favorite because it’s a unique formula. It combines polyhydroxy acids (PHAs) with signal peptides.

PHAs like maltobionic acid and gluconolactone are gentle enough to use around the eyes for smoothing out that skin. And with the help of signal peptides, the eye cream boosts collagen synthesis and reveals brighter and smoother skin. It has caffeine and ginseng to tighten and brighten the under-eyes. Plus, it has a naturally radiant finish to literally brighten the eyes.

Olay Vitamin C + Peptide 24 Eye Cream

Olay Vitamin C + Peptide 24 Eye Cream - Best Drugstore Peptide Eye Cream

This is a vitamin C eye cream enriched with signal peptides. So it’s heavy on brightening and easy on the peptides. It’s made with a very effective and stable vitamin C derivative to fade the look of dark circles and discolorations around the eyes without irritating the skin. And it has niacinamide to enhance those effects.

The hypoallergenic formula is fragrance-free and doesn’t feel sticky on the skin either. It hydrates the skin and locks in moisture while vitamin C works to brighten the skin. This isn’t that cheap. But still, it’s one of the best drugstore peptide eye creams that offer peptides together with antioxidants in a gentle, fast-absorbing formula.

Medik8 Eye Peptides

Medik8 Eye Peptides

Last but not least, we have this medical-grade eye cream. It effectively infuses the skin with neuropeptides and signal peptides formulated into a featherlight base. The texture is formulated around humectants, which ensures maximum skin penetration so that the peptides work better.

If you’re prone to milia, or if you have oily under-eyes and eyelids, apply this and leave it. But if you have very dry under-eyes, you can use this as a treatment and apply a more emollient eye cream over it to increase moisture. Either way, the peptide-infused eye cream stimulates collagen and elastin synthesis to iron out wrinkles around the eyes, and lift and firm the eye area.

So these are some of the best peptide eye creams out there. They allow you to address age-related issues in the eye area including wrinkles, under-eye bags, droopy eyelids, and discolorations. If retinol seems too much for your under-eye area, peptides are the next best thing. And if you’re dealing with fine lines under your eyes, check out how to get rid of under-eye wrinkles and minimize their appearance.


  1. Ferreira MS, Magalhães MC, Sousa-Lobo JM, Almeida IF. Trending Anti-Aging Peptides. Cosmetics. 2020; 7(4):91.
  2. Schagen, S. (2017). Topical Peptide Treatments with Effective Anti-Aging Results. Cosmetics4(2), 16.
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