The Best Peptide Eye Creams To Revitalize Your Under-Eyes

Best Peptide Eye Creams

We independently select and review the products we recommend. If you make a purchase using our affiliate links below, we may earn a commission.

Now that peptides had their trial run in the form of serums and creams, we have peptide eye creams taking over the skincare world by storm. Peptides, or polypeptides, are chains of amino acids.

And don’t worry, they’re an uncomplicated bunch. Once you know which one works on what, you can make use of peptides in your eye creams for pretty much anything.

Whether it’s for under-eye bags, under-eye wrinkles, crow’s feet, or dark circles, peptide eye creams have serious anti-aging benefits. To help you find the right one for you, below is our round-up of the best peptide eye creams on the market.

Benefits of Peptide Eye Creams

The benefit of a peptide eye cream will depend largely on which types of peptides it contains. In case you missed our guide to peptides, they come in four different types.

Eye creams with neuropeptides are touted to be nature’s Botox, which is amazing when you want to soften fine lines instantly. Signal peptide eye creams help boost collagen production and firm the skin around the eyes.

Copper peptide eye creams have anti-inflammatory and antioxidant benefits. And eye creams with enzyme-inhibiting peptides can do several things from preventing collagen loss to even helping with dark circles.

However, know that peptides don’t show up as peptides on your ingredient list. They show up with their official names. A copper peptide eye cream will have tripeptide-1 on the ingredient list.

A signal peptide eye cream will have palmitoyl tripeptide-1 or palmitoyl oligopeptide, which is commonly known as Matrixyl and is the brand name of that specific peptide.

Similarly, a neuropeptide eye cream will have the name acetyl hexapeptide-8, commonly known as Argireline, on the ingredient list.

Usually, eye creams contain multiple peptides from the same category to maximize the effects. Some eye creams contain different types of peptides, which makes them incredibly multi-tasking too!

The good thing is you don’t need to look up anything. I’ve rounded up some amazing eye creams made with peptides.

And I’ll dive into each one and tell you which peptides it contains to help you look past vague terms like firming peptides or collagen peptides.

Best Peptide Eye Creams

Find below the best peptide eye creams to tackle fine lines, wrinkles, under-eye bags, and more!

1. Kiehl’s Super Multi-Corrective Anti-Aging Eye Cream

Kiehl's Super Multi-Corrective Anti-Aging Eye Cream
Gentle formula
Packs signal peptides
Layers well under makeup

This is one of the first peptide eye creams I’ve ever used for my crow’s feet and it’s formulated with signal peptides. I’ve kept it in my arsenal over the years because even though it’s an anti-aging eye cream, it’s super gentle on my sensitive eyes. The formula also contains niacinamide to reduce discolorations around the eyes.

It also has hyaluronic acid to plump fine lines and caffeine to help de-puff. The texture of it is almost gel-like, and when applied, it disappears into the skin and leaves no visible residue. It doesn’t pill under makeup either. So you can layer under your concealer comfortably!

Key Ingredients: Signal peptides, niacinamide
Key Benefits: Softens under-eye wrinkles, de-puffs
Size: 0.5 oz/15 ml
Good To Know: Fragrance-free

2. Strivectin Peptight 360 Tightening Eye Serum

Strivectin Peptight 360 Tightening Eye Serum
Peptide eye serum
Applicator tip

This is a peptide eye serum. Compared to creams, serums are more effective because they absorb better and give more noticeable results. Also, you can use this all around the eye area including the upper eyelids, which is great if you deal with puffy eyes. I usually keep my Jade roller in the fridge to keep it cool so that I can massage my eye area to reduce puffiness.

But this peptide eye serum has an applicator tip you can use to de-puff the eyes, get rid of eye bags, and work the product into the skin. Plus, it has niacinamide and caffeine to reduce dark circles and tighten the skin too. Note that even though this is pricey, it’s twice the size of a regular eye serum.

Key Ingredients: Signal peptides, caffeine, Kakadu plum extract
Key Benefits: Brightens, reduces under-eye bags, hydrates
Size: 1 oz/30 ml
Good To Know: Fragrance-free

3. iS Clinical Youth Eye Complex

iS Clinical Youth Eye Complex
Packs vitamin C
Brightening vitamin K

This one utilizes a neuropeptide. Much like Argireline, the famous peptide that mimics Botox, it works by reducing muscle contraction and easing the look of expression lines around the eyes. And it contains a copper peptide, which works as an antioxidant and helps with skin repair.

The eye cream instantly plumps the skin with hyaluronic acid and panthenol and soothes the eye area with Centella Asiatica. Plus, it contains vitamins C, A, and E to infuse the eye area with potent antioxidants. If you’re looking for an anti-aging formula for mature skin, deep wrinkles, fine lines, dehydration lines, and sun damage around the eyes, this is a well-deserving investment.

Key Ingredients: Neuropeptides, copper peptides, vitamin C, vitamin E
Key Benefits: Hydrates, improves radiance, tightens
Size: 0.5 oz/15 ml
Good To Know: Fragrance-free

4. Derma-E Advanced Peptides & Flora Collagen Eye Cream

Derma-E Advanced Peptides & Collagen Eye Cream - Best Affordable  Peptide Eye Cream
Drugstore pick

If you’re looking for an affordable peptide eye cream, this can be as helpful as the rest. Besides signal peptides and neuropeptides, this one’s got a blend of antioxidants like green tea, and vitamins A, C, and E to undo sun damage around the eyes.

But it also has a very moisturizing texture, which is amazing if you have very dry under-eyes. It instantly plumps up the skin and fills in fine lines with humectants and emollients like glycerin, and macadamia seed oil.

Key Ingredients: Neuropeptides, signal peptides, green tea, vitamin C
Key Benefits: Moisturizes, brightens, softens fine lines
Size: 0.5 oz/15 ml
Good To Know: Fragrance-free, vegan, cruelty-free

5. Biossance Squalane + Peptide Eye Gel

Biossance Squalane + Peptide Eye Gel
Clean peptide eye cream
Fast absorbing gel

Some people don’t enjoy a heavily occlusive eye cream because it can cause milia. When that’s the case, eye serums and eye gels are the way to go. They don’t contain comedogenic oils. The light texture of this one is perfect if you’re prone to milia. Additionally, if you’re an instant gratification seeker like me, this one is made with neuropeptides only.

So you’ll get instantly smooth skin around the eyes all thanks to Argireline, and another neuropeptide with advanced de-puffing benefits. The eye gel has squalane, aloe, panthenol, and hyaluronic acid to quench dry skin and packs caffeine to minimize puffy eyes. It’s an effective peptide eye cream to renew the under-eyes without resorting to irritating ingredients.

Key Ingredients: Neuropeptides, niacinamide, caffeine, squalane
Key Benefits: Illuminates, depuffs, smoothes the eye area
Size: 0.5 oz/15 ml
Good To Know: Fragrance-free, vegan, cruelty-free

6. Exuviance Age Reverse Eye Contour

Exuviance Age Reverse Eye Contour
Packs PHAs

Speaking of irritating ingredients, not all skin types can tolerate exfoliants, especially when it comes to the under-eye area. On the flip side, exfoliating the skin around the eyes is super helpful in getting rid of flaky under-eyes, loose skin, and fine lines. For that reason, this is my personal favorite because it’s a unique formula. It combines polyhydroxy acids (PHAs) with signal peptides.

PHAs like maltobionic acid and gluconolactone are gentle enough to use around the eyes for smoothing out the skin. And with the help of signal peptides, the eye cream boosts collagen synthesis and reveals brighter and smoother skin. It has caffeine and ginseng to tighten and illuminate the under eyes. Plus, it has a naturally radiant finish to leave the eye area bright.

Key Ingredients: Signal peptides, gluconolactone, maltobionic acid
Key Benefits: Gently exfoliates, stimulates collagen
Size: 0.5 oz/15 ml

7. Olay Vitamin C + Peptide 24 Eye Cream


This is a vitamin C eye cream enriched with signal peptides. So it’s heavy on brightening and easy on the peptides. It’s made with a very effective and stable vitamin C derivative to fade the look of dark circles and discolorations around the eyes without irritating the skin. And it has niacinamide to enhance those effects.

The hypoallergenic formula is fragrance-free and doesn’t feel sticky on the skin either. It hydrates the skin and locks in moisture while vitamin C works to brighten the skin. This isn’t that cheap. But still, it’s one of the best drugstore peptide eye creams that offer peptides together with antioxidants in a gentle, fast-absorbing formula.

Key Ingredients: Signal peptides, vitamin C, niacinamide
Key Benefits: Prevents free radical damage, firms, reduces dark circles
Size: 0.5 oz/15 ml
Good To Know: Fragrance-free

8. Medik8 Eye Peptides

Medik8 Eye Peptides
Peptide eye serum

Last but not least, we have this medical-grade eye cream. It effectively infuses the skin with neuropeptides and signal peptides formulated into a featherlight base. The texture is formulated around humectants, which ensures maximum skin penetration so that the peptides work better.

If you’re prone to milia or have oily under-eyes and eyelids, apply this and leave it. But if you have very dry under-eyes, you can use this as a treatment and apply a more emollient eye cream over it to increase moisture. Either way, the peptide-infused eye cream stimulates collagen and elastin synthesis to iron out wrinkles around the eyes and lift and firm the eye area.

Key Ingredients: Neuropeptides, signal peptides, rice protein
Key Benefits: Firms under-eyes, hydrates
Size: 0.5 oz/15 ml
Good To Know: Fragrance-free, vegan-friendly, cruelty-free

So these are some of the best peptide eye creams out there. They allow you to address age-related issues in the eye area including wrinkles, under-eye bags, droopy eyelids, and discolorations. If retinol seems too much for your under-eye area, peptides are the next best thing.

What To Look For in a Peptide Eye Cream

The Right Peptides

As I’ve mentioned, different peptides have different benefits. If you’re looking to minimize under-eye wrinkles, look for signal peptides to stimulate collagen production. If you want an instant smoothing effect for crow’s feet, look for neuropeptides like Argireline. If you’re looking for skin repair, look for copper peptides in your eye cream.

Other Ingredients

Peptides are majorly anti-aging. So to make sure you get the most bang for your buck, look for other anti-aging ingredients such as antioxidants, exfoliants, or retinol. This will make your eye cream more targeted. For example, a peptide eye cream with vitamin C or niacinamide will also reduce dark circles. Similarly, if you have puffiness or under-eye bags, a peptide eye cream made with caffeine will work better to tighten the eye area.


Scroll to Top